【興大報(bào)告 Xing Da Lecture 538】
發(fā)布時(shí)間：2017-11-16 來(lái)源:北大化學(xué)
題 目
Recent Advances in Carbene Chemistry: Concepts and Applications
報(bào)告人
Prof. Alois Fürstner
Max-Planck-Institut für Kohlenforschung, Germany
時(shí) 間
2017年11月24日，下午2:00
地 點(diǎn)
化學(xué)樓A204/206
主請(qǐng)人
王劍波
BSTRACT
報(bào)告摘要
This lecture intends to showcase some unconventional ways of harnessing the reactivity of alkynes via highly selective metal-catalyzed transformations. After a short review of our work in the area of triple bond metathesis, some unorthodox addition reactions to internal alkynes will be discussed in detail.
The use of carbophilic Lewis acids based on gold, platinum or rhodium provides many opportunities for the selective functionalization of triple bonds. Although it is well accepted that the reactions usually proceed via metal carbene intermediates, the actual nature of such species was subject to speculation. Only recently has our group managed to isolate reactive carbenes of gold and rhodium. The structural features of these species and the preparative implications will be discussed in some detail.
Moreover, unprecedented ruthenium-catalyzed trans-hydrogenation, trans-hydroboration and trans-hydrostannation reactions will be presented. These unconventional transformations are also thought to proceed via metal-carbene intermediates, some of which have also been isolated and fully characterized. Selected applications to target-oriented synthesis are meant to showcase the current state of development.
★ Professor Alois Fürstner ★
Alois Fürstner教授是德國(guó)有機(jī)化學(xué)領(lǐng)域的頂尖科學(xué)家，在世界范圍內(nèi)享有很高的聲譽(yù)。Fürstner教授的研究涉及有機(jī)化學(xué)的多個(gè)領(lǐng)域：烯烴以及炔烴的復(fù)分解反應(yīng)，?－酸催化，鐵催化，天然產(chǎn)物全合成等。Fürstner教授獲得過(guò)多個(gè)重要的國(guó)際獎(jiǎng)項(xiàng)，他曾經(jīng)擔(dān)任過(guò)德國(guó)馬普所的常務(wù)所長(zhǎng)（Managing Director），以及目前擔(dān)任Angewandte Chemie雜志編委會(huì)主席。
Alois Fürstner’s scientific interests relate to organometallic chemistry and homogenous catalysis, including applications thereof to target oriented synthesis. An early success was the development of the first NHK-reactions catalytic in chromium. Further notable lines of research comprise extensive studies on alkene- and alkyne metathesis, pioneering contributions to the field of ?-acid catalysis based on platinum and gold, as well as the development and mechanistic investing of iron-catalyzed reactions. These methods opened concise and flexible entries into many bioactive natural products.
His research was recognized by several awards, including the Leibniz Award of the German Science Foundation (1999), the IUPAC-Thieme Prize (2000), an ACS Arthur C. Cope Scholar Award (2002), the inaugural Mukaiyama Award (Japan, 2005), the Otto-Bayer-Prize of the German Chemical Society (2013), the Gay-Lussac/Humboldt Prize (France, 2014), and the ACS H. C. Brown Award (2016).
Vita
2009-2011 Managing Director of the Max-Planck-Institut für Kohlenforschung
since 1998 Director at the Max-Planck-Institut für Kohlenforschung and Professor at the Technical University of Dortmund
1993-1998 Group leader at the Max-Planck-Institut für Kohlenforschung and Lecturer at the University of Dortmund
1992 “Habilitation” in Organic Chemistry at the Technical University Graz, Austria
1990-1991 Postdoctoral fellow at the University of Geneva, Switzerland (W. Oppolzer)
1987 PhD at the Technical University Graz, Austria (H. Weidmann)
1962 born in Bruck/Mur (Austria)
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